The Effects of Partial Replacement of Animal Proteins with Soy Proteins in Children with Hyperlipoproteinemia on Blood Lipids

Abstract

This study had been done onfıve 9-12 years old (4 males, one fenıtıle) patients \vith hyperlipoproteinemia in the Department o f Metabolism, Ihscuı Doğramacı Children Hospital, Hacettepe University Faculty o f Mediciııe. The patients \vere not ıısiııg any lipid lo\vering drugs,four children \vere type IIa and one \vas type IV. In the study, the effects ö f partici l replacement o f animal proteins with soy proteins lıave been evaluated. At the beginııing o f the study dietary habits o f the children prior to treatment hav e been investigated. The study was carried out in ftvo phases, each lasting one nıonth and patients nutrient regııirements determined according to RDA. In phase I, 12% o f energy was supplied by p ro te ins (animal 60%, vegetable 40 %), 25% from fa t (satıırated 5%, monounsaturated 10 %, polyunsaturated 10 %) and restfrom carbohydrates. Cholesterol intake was plaııned as 150 nıglday. In phase II, animal proteins were redııced by 10% and replaced with soybeaııs p ro teins which \vas given by the special produet called Nutri- Soya. In the beginııing, phase I and II o f the study fo - ur o f the patients \vere less than 50th percentile o f weight and height according to age. There were no statistical dijference betweeıı t\vo phases. In the beginııing, phase I and II , blood lipids o f patients were determined. When soy diet was taken total cholesterol, triglyceride, VLDL-cholesterol, and Apo B-100 decreased 9.6%, 28.1%, 28.1%, 5.2% respeetively. Ho\vever diffe r ence was not statistically sigııificaııt. This can be attributed to the short study period and sıııall number of patients.