The Influence Of Dıetary Fats On The Effects Of Recombınant Human Tumour Necrosıs Factor-A In Rats; Proteın Synthesıs In Lıver, Lung, Kıdney and Muscle Of Rats

Abstract

Cytokines mediate many of the metabolic changes that occur during infection and are implicated in chronic inflammatory diseases such as rheumatoid arthritis. Fish oil has been shown to modify their inflammatory effects by alteration of eicosanoid (i.e. prostaglandins, leukotrienes etc) metabolism. This study compares the response of rats to TNF-a after six weeks of feeding diets rich in n-6 polyunsaturated fatty acids (PUFAS) fed as corn oil, or poor in n-6 PUFAs fed as fishoil. Protein fractional synthetic rates and content were measured in liver, lung, kidney and muscle. In rats fed corn oil, rates of protein synthesis were increased by 38.5, 54.7 and 55.5 % in the liver, lung and kidney, respectively. Fish oil prevented the increase in protein synthesis in liver, lung and kidney. There were no changes occured in the rate of protein synthesis of muscle in the groups.