Effect Of Dıetary Nucleotıdes On The Lıpoproteın Pattern Durıng The Neonatal Perıod

Abstract

The aim of this study was to investigate the effects of dietary nucleotides on the plasma lipoprotein pattern in term neonates. We examined the lipoprotein pattern of 21 term neonates in 3 groups. Groups I (n:7), were fed with human milk, group II (n:7) with a milk formula and group III (n:7), with a nucleotides-supplemented milk formula. Anthropometric measurements of the neonates and blood samples to determine the serum lipoprotein levels were obtained at one week and at 4 weeks of age. No differencea in growth rates of infants were found fed with human milk, milk formula or nucleotidessupplemented formula. Also triglyceride, cholesterol, high density lipoprotein (HDL) and low-density lipoprotein levels (LDL) didn't show any significant differences at one week and at 4 weeks of age. Variance analysis among 3 groups showed significant difference in the serum triglyceride levels at one week of age (F=9.81, p<0.05) HDL levels were found to be also significant (F=7.36, p<0.05) at 4 weeks of age. In conclusion, dietary supplementation of nucleotides were found to decrease serum triglyceride levels and were effective in the lipoprotein metobolism in neonates.