Probiotics and Their Effects on Wound Healing: The Effect Mechanisms on Angiogenesis

Abstract

Probiotics have been studied in a large number of disease groups from gastrointestinal system disorders to depression, and it has been reported that they may have positive effects in the aforementioned diseases. The reported positive effects of probiotics are thought to be achieved by enriching the living microbiota during disease development and treatment. Wound healing is a process that is under the influence of many different mechanisms. Bacteria may have beneficial or adverse effects in this process according to their species. Recent studies have shown that some probiotic bacterial strains are effective on wound healing with topical application or by their systemic effects. It has been reported that probiotic bacteria are more effective than antibiotics, particularly in gastric ulcers with antibiotic resistance, by their actions on angiogenesis. Further studies are needed to determine the mechanisms of effect of probiotics and which species of bacteria are effective.