Effects of Dietary Fibre and Colon Microbiota on Colon Cancer Risk

Abstract

Dietary fibre has significant amount of benefits on human health. Dietary fibre is a nutrient which is the most common subject of studies about colon microbiota and colon cancer. There are two types of dietary fibres according to their fermentability in colon such as soluble and insoluble fibre. Soluble fibre by increasing the synthesis of short chain fatty acids (SCFA) has beneficial anti-inflammatory, anti-tumor, anti-proliferative, prebiotic and dysbiosis prevention effects. Insoluble fibres increase the passage speed and decrease absorption of cancinogenic substances such as secondary bile acids. Dietary fibre may decrease risk of colon cancer through these potential effects. The aim of this review is to discuss the potential effects of dietary fibre and colon microbiota on colon cancer.