Diabetes Mellitus and Oxidative Stress

Abstract

Oxidative stress plays an important role in progress of diabetes mellitus and its complications. Exposing to hyperglycemia for a long term causes oxidative stres. Poliol pathway, advanced glycation end-products (AGE) formation, auto-oxidation of glucose, increased protein kinaz c activation and hexosamine pathway are the main mechanisms which cause the hyperglycemia induced free radical production. Increased nicotinamide adenine dinucleotide activation also affects the progression of oxidative stress. Reductions in antioxidant parameters such as glutathione, superoxide dismutase, catalase which are seen in diabetes mellitus accelarate the oxidative damage and cause various complications to occur. In this review, oxidative stress and its reasons have been summarized.