Non-Celiac Gluten Sensitivity

Abstract

In the last few years, non-celiac gluten sensitivity has received great interest from the scientific community. The disease is characterized by gastrointestinal or extraintestinal symptoms that respond with the extraction of gluten from the diet of patients not diagnosed with celiac disease or wheat allergy. It gives similar symptoms like irritable bowel syndrome. Prevalence is reported to be slightly more common than celiac disease. It has been reported mostly in adults, especially in the 30-50 age group and female gender, but has also been reported in pediatric patients. Gluten free diet therapy is recommended for patients with non celiac gluten sensitivity but the amount of gluten that affects patients varies according to individuals. Symptoms disappear after a gluten free diet. In this article, current information about non-celiac gluten sensitivity and the differences from celiac disease are reviewed. Possible mechanisms for the pathophysiology of this new condition are discussed.