The Effect of Gluten-free Diet and Microbiota Focused Treatment on Microbiota Alterations in Children with Celiac Disease

Abstract

Celiac is a small intestine disease with severe gastrointestinal or extraintestinal disorders following gluten consumption in individuals with genetic predisposition. Along with genetic factors, environmental factors are thought to play a role in the pathogenesis of the disease. In recent years, the role of alterations in intestinal microbiota in the pathogenesis of celiac disease has been shown and clues have been provided for potential non-invasive treatments. Studies show microbiota alterations during active and treatment periods of celiac. However, there is evidence showing that gluten-free diets may also contribute to these alterations. Therefore, host, diet and immune system interactions should be evaluated in modulation of intestinal microbiota. In this review, the effect of gluten-free diet and microbiota-focused therapies on intestinal microbiota in pediatric celiac patients was evaluated.