Renal Diseases and Lipid Metabolism

Abstract

Kidneys play a role in liquid-electrolyte balance control, blood metabolic waste removal, erythrocyte production, blood pressure regulation, blood volume and pH control by controlling the acid-base balance. Chronic Renal Failure (CRF) is defined as a chronic and progressive deterioration in the metabolic-endocrine function of the kidney with fluid-solute balance as a result of a decrease in glomerular filtration value. In chronic renal failure, structural changes such as epithelial damage, glomerular and parietal basement membrane damage, arteriol and capillary vessel wall thickening and lumen narrowing, sclerosis in glomeruli, tubules and membranes, decrease in glomerular filtration rate (GFH), and nephron destruction are seen. In chronic renal failure (CRF), a reduction in renal function, plasma lipid and lipoprotein metabolism, both amount and composition of lipoproteins, and apolipoproteins, significant changes occur and abnormal lipid metabolism is common in kidney patients.